Publications

2024

Waters, B. J., Birman, Z. R., Wagner, M. R., Lemanski, J., & Blum, B. (2024). Islet architecture in adult mice is actively maintained by Robo2 expression in β cells. Developmental biology, 505, 122–129. https://doi.org/10.1016/j.ydbio.2023.11.003.


2023

Adams, M. T., Waters, B. J., Nimkulrat, S. D., & Blum, B. (2023). Disrupted glucose homeostasis and glucagon and insulin secretion defects in Robo βKO mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 37(8), e23106. https://doi.org/10.1096/fj.202200705RR.

2022

Waters, B. J., & Blum, B. (2022). Axon Guidance Molecules in the Islets of Langerhans. Frontiers in endocrinology, 13, 869780. https://doi.org/10.3389/fendo.2022.869780.

Adams, M. T., & Blum, B. (2022). Determinants and dynamics of pancreatic islet architecture. Islets, 14(1), 82–100. https://doi.org/10.1080/19382014.2022.2030649.


2021

Adams, M. T., Dwulet, J. M., Briggs, J. K., Reissaus, C. A., Jin, E., Szulczewski, J. M., Lyman, M. R., Sdao, S. M., Kravets, V., Nimkulrat, S. D., Ponik, S. M., Merrins, M. J., Mirmira, R. G., Linnemann, A. K., Benninger, R. K., & Blum, B. (2021). Reduced synchroneity of intra-islet Ca2+ oscillations in vivo in Robo-deficient β cells. eLife, 10, e61308. https://doi.org/10.7554/eLife.61308.

Nimkulrat, S. D., Bernstein, M. N., Ni, Z., Brown, J., Kendziorski, C., & Blum, B. (2021). The Anna Karenina Model of β-Cell Maturation in Development and Their Dedifferentiation in Type 1 and Type 2 Diabetes. Diabetes, db210211. Advance online publication. https://doi.org/10.2337/db21-0211.

Gilbert, J. M., Adams, M. T., Sharon, N., Jayaraaman, H., & Blum, B. (2020). Morphogenesis of the islets of Langerhans is guided by extra-endocrine Slit2/3 signals. Mol Cell Biol, 41(3), e00451-20. Advance online publication. https://doi.org/10.1128/MCB.00451-20.


2018

Adams, M. T., Gilbert, J. M., Hinojosa Paiz, J., Bowman, F. M., & Blum, B. (2018). Endocrine cell type sorting and mature architecture in the islets of Langerhans require expression of Roundabout receptors in β cells. Scientific reports, 8(1), 10876. https://doi.org/10.1038/s41598-018-29118-x.

Gilbert, J. M., & Blum, B. (2018). Synaptotagmins Tweak Functional β Cell Maturation. Developmental cell, 45(3), 284–286. https://doi.org/10.1016/j.devcel.2018.04.018.


2015

Ben-Zvi, D., Barrandon, O., Hadley, S., Blum, B., Peterson, Q. P., & Melton, D. A. (2015). Angptl4 links α-cell proliferation following glucagon receptor inhibition with adipose tissue triglyceride metabolism. Proc Natl Acad Sci U S A, 112(50), 15498–15503. https://doi.org/10.1073/pnas.1513872112.


2014

Blum, B., Roose, A. N., Barrandon, O., Maehr, R., Arvanites, A. C., Davidow, L. S., Davis, J. C., Peterson, Q. P., Rubin, L. L., & Melton, D. A. (2014). Reversal of β cell de-differentiation by a small molecule inhibitor of the TGFβ pathway. eLife, 3, e02809. https://doi.org/10.7554/eLife.02809.


2012

Blum, B., Hrvatin, S., Schuetz, C., Bonal, C., Rezania, A., & Melton, D. A. (2012). Functional beta-cell maturation is marked by an increased glucose threshold and by expression of urocortin 3. Nature biotechnology, 30(3), 261–264. https://doi.org/10.1038/nbt.2141.


2009

Blum, B., & Benvenisty, N. (2009). The tumorigenicity of diploid and aneuploid human pluripotent stem cells. Cell cycle (Georgetown, Tex.), 8(23), 3822–3830. https://doi.org/10.4161/cc.8.23.10067.

Straussman, R., Nejman, D., Roberts, D., Steinfeld, I., Blum, B., Benvenisty, N., Simon, I., Yakhini, Z., & Cedar, H. (2009). Developmental programming of CpG island methylation profiles in the human genome. Nat Struct Mol Biol, 16(5), 564–571. https://doi.org/10.1038/nsmb.1594.

Blum, B., Bar-Nur, O., Golan-Lev, T., & Benvenisty, N. (2009). The anti-apoptotic gene survivin contributes to teratoma formation by human embryonic stem cells. Nature biotechnology, 27(3), 281–287. https://doi.org/10.1038/nbt.1527.


2008

Blum, B., & Benvenisty, N. (2008). The tumorigenicity of human embryonic stem cells. Adv Cancer Res, 100, 133–158. https://doi.org/10.1016/S0065-230X(08)00005-5.


2007

International Stem Cell Initiative, Adewumi, O., Aflatoonian, B., Ahrlund-Richter, L., Amit, M., Andrews, P. W., Beighton, G., Bello, P. A., Benvenisty, N., Berry, L. S., Bevan, S., Blum, B., Brooking, J., Chen, K. G., Choo, A. B., Churchill, G. A., Corbel, M., Damjanov, I., Draper, J. S., Dvorak, P., … Zhang, W. (2007). Characterization of human embryonic stem cell lines by the International Stem Cell Initiative. Nature biotechnology, 25(7), 803–816. https://doi.org/10.1038/nbt1318.

Blum, B., & Benvenisty, N. (2007). Clonal analysis of human embryonic stem cell differentiation into teratomas. Stem cells (Dayton, Ohio), 25(8), 1924–1930. https://doi.org/10.1634/stemcells.2007-0073.


2005

Cassuto, H., Kochan, K., Chakravarty, K., Cohen, H., Blum, B., Olswang, Y., Hakimi, P., Xu, C., Massillon, D., Hanson, R. W., & Reshef, L. (2005). Glucocorticoids regulate transcription of the gene for phosphoenolpyruvate carboxykinase in the liver via an extended glucocorticoid regulatory unit. J Biol Chem, 280(40), 33873–33884. https://doi.org/10.1074/jbc.M504119200.


2003

Reshef, L., Olswang, Y., Cassuto, H., Blum, B., Croniger, C. M., Kalhan, S. C., Tilghman, S. M., & Hanson, R. W. (2003). Glyceroneogenesis and the triglyceride/fatty acid cycle.  J Biol Chem, 278(33), 30413–30416. https://doi.org/10.1074/jbc.R300017200.

Olswang, Y., Blum, B., Cassuto, H., Cohen, H., Biberman, Y., Hanson, R. W., & Reshef, L. (2003). Glucocorticoids repress transcription of phosphoenolpyruvate carboxykinase (GTP) gene in adipocytes by inhibiting its C/EBP-mediated activation. J Biol Chem, 278(15), 12929–12936. https://doi.org/10.1074/jbc.M300263200.